Sometimes, we need to hit an endpoint URL which is TLS 1.2 enabled and SOAP UI does not support it by default. Therefore, we could follow given below steps for necessary tuning:-
(1) Navigate to C:\Program Files\SmartBear\SoapUI-5.2.1\bin folder.
(2) Edit SoapUI-5.2.1.vmoptions file with any text editor.
(3) Add following entry and save the file. It will only enable TLS 1.2 protocol.